Emergency crews have rushed to a stage after six-vehicles crashed on a M60.
The pound happened during about 7.30am between connection 20 for Blackley and connection 21 for Hollinwood.
It is now causing delays of around an hour for motorists.
The M6 northbound nearby Warrington has also been sealed after a lorry jack-knifed following a crash.
The lorry crashed with a automobile during around 8.30am.
North West Motorway Police tweeted: “There is a FULL closure in place.
“If we haven’t nonetheless set off greatfully find an choice route. Those in a traffic, greatfully wait for military instructions.”
There are now tailbacks stretching to connection 20, according to trade website Inrix.